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Nutrition HubModerate EvidenceActionability: Moderate

Folate & Methylation

The MTHFR gene role in cellular methylation, folate processing, and dietary requirements.

Biological Mechanism & Scientific Context

MTHFR converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the active form of folate used to remethylate homocysteine into methionine. Common polymorphisms reduce enzymatic activity, which can be mitigated through whole-food folate consumption.

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