Scientific Database / Evidence Lab

The Evidence Lab Database

A comprehensive, transparent repository of genetic variations evaluated under Genostride's Gene-to-Action Framework. We catalog evidence, expected effect size, and actionability to counter wellness industry hyperbole.

Methodological Disclosure:We exclude findings from non-replicated, small candidate gene studies or studies without human validation. A rating of "Emerging" or "Limited" indicates that while interesting, the marker is not yet ready to guide everyday actions.

Evaluated Genomic Variations (6)database_rev: 2026.07.01

Marker (Gene / SNP)	Biological Trait	Evidence	Expected Effect	Actionability	Key Biological Insight	Reference
CYP1A2rs762551	Caffeine metabolism speed	Strong Evidence	Effect: Moderate	Actionability: High	Determines fast (A/A) vs slow (A/C, C/C) metabolism. Slow metabolizers see sleep disruption from late caffeine.	Read Analysis
LCTrs4988235	Lactose tolerance persistence	Strong Evidence	Effect: Potentially meaningful	Actionability: High	Modulates enzyme lactase persistence in adulthood. T/T or T/C persist, C/C indicates lactose non-persistence.	Read Analysis
ACTN3rs1815739	Fast-twitch muscle fiber efficiency	Moderate Evidence	Effect: Moderate	Actionability: Moderate	R/R variant produces actinin-3 in fast-twitch fibers, linked to sprint performance. X/X lack it, favoring endurance training.	Read Analysis
MTHFRrs1801133	Folate conversion pathway speed	Moderate Evidence	Effect: Small	Actionability: Moderate	677C>T variant reduces enzyme speed. Addressed by eating whole-food folate (leafy greens), not synthetic supplements.	Read Analysis
FTOrs9939609	Appetite and satiety regulation	Strong Evidence	Effect: Small	Actionability: Moderate	Associated with slightly higher satiety latency. Impact is completely mitigated by eating high-protein and high-fiber diets.	Read Analysis
CLOCKrs1801260	Chronotype circadian timing	Moderate Evidence	Effect: Moderate	Actionability: Moderate	Certain alleles shift natural sleep-wake times by 30-40 minutes. Useful for understanding work scheduling limits.	Read Analysis

Understanding the Grading

The Evidence Lab evaluates each genetic variation by analyzing multiple peer-reviewed clinical trials, meta-analyses, and genome-wide association studies (GWAS).

Many wellness platforms promote supplements and diets using "Emerging" or "Limited" markers. We restrict positive recommendations to "Strong" or "Moderate" markers with clear, actionable effect sizes.

Rating Definitions:

Strong: Multiple replicated large cohorts and clear physiological mechanisms.

Moderate: Good cohort replication; effect size is minor or modulated by environment.

Limited / Mixed: Discrepancies between study populations or un-replicated pilot data.