Caffeine Metabolism
How CYP1A2 gene variants modulate caffeine clearance rates and impact sleep hygiene and cardiovascular strain.
Biological Mechanism & Scientific Context
Hepatic cytochrome P450 1A2 (CYP1A2) is responsible for approximately 95% of caffeine clearance. Single nucleotide variations dictate whether you process caffeine rapidly or retain active metabolites for over 10 to 12 hours, directly influencing deep sleep architecture.
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