Circadian Chronotypes
How internal biological clocks and CLOCK gene variations determine natural peak alertness hours and sleep windows.
Biological Mechanism & Scientific Context
Our central suprachiasmatic nucleus master clock is regulated by transcriptional feedback loops between CLOCK, BMAL1, PER, and CRY genes. Polymorphisms within these loci shift endogenous rhythm phase by 30 to 60 minutes, determining morning vs evening preference.
Interactive Tool Available
Test your genotype interaction in the Simulator
Select your genetic profile and daily habit timing to visualize real-time physiological response.