Caffeine Sleep Sensitivity
Clearance rates (CYP1A2) and adenosine receptor sensitivity (ADORA2A) influence on evening caffeine sleep latency.
Biological Mechanism & Scientific Context
Even among fast caffeine metabolizers, differences in the ADORA2A adenosine receptor modulate whether residual caffeine molecules block adenosine binding, increasing nocturnal awakenings and suppressing restorative slow-wave sleep.
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