Cognitive Performance & Neuroplasticity
Genomic factors associated with BDNF secretion, working memory, attention shifting, and mental endurance.
Biological Mechanism & Scientific Context
Brain-Derived Neurotrophic Factor (BDNF) is critical for long-term potentiation and synaptic plasticity. The Val66Met polymorphism impairs activity-dependent BDNF secretion in the hippocampus, affecting memory retention and responsiveness to aerobic exercise for mood enhancement.